Endocrine Abstracts

Background: ACTH concentrations remain typically elevated in patients with Addison’s disease. We present a case of an extremely potent oral contraceptive pill (OCP) induced increase in total cortisol resulting in inhibition of ACTH secretion that was normalized on OCP withdrawal.Case Presentation: A 20-year old female was diagnosed with Addison’s disease [cortisol 1.59 µg/dl, ACTH>500 pg/ml (0-65)] and...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Back groundBoth pregnancy and polycystic ovary syndrome (PCOS) constitute insulin-resistant states, while gestational diabetes (GDM) is associated with adverse pregnancy outcomes. Though screening for GDM is typically performed later in pregnancy, some women demonstrate significant insulin resistance (IR) and develop GDM even in 1st trimester. We have endeavoured to compare surrogate IR indices in 1st trimester pregnant women and in...